Childhood Myelodysplastic Syndrome in Belarus
نویسندگان
چکیده
منابع مشابه
Myelodysplastic syndrome.
The last decade has witnessed a multistep evolution in the understanding of the natural history, clinical manifestations, and some of the molecular mechanisms that underlie the ineffective hematopoiesis and leukemic transformation in the myelodysplastic syndrome (MDS). The international prognostic scoring system, FAB, and WHO classifications have helped define specific subgroups with their char...
متن کاملMyelodysplastic Syndrome
The hallmark of neoplastic disease, including myelodysplastic syndrome (MDS), is clonal proliferation of cells. Clonal proliferation is the consequence of acquired somatic mutation that confers a proliferative advantage to cells. For the myelodysplastic syndrome, the ability to identify clonally derived cells has provided valuable information about the molecular pathogenesis of the disease, the...
متن کاملMyelodysplastic syndrome.
During the past 15 years, important progress has been made in the understanding of the biology and prognosis of myelodysplastic syndrome (MDS). MDS is a clonal disorder characterized by ineffective hematopoiesis, which can lead to either fatal cytopenias or acute myelogenous leukemia (AML). Risk-adapted treatment strategies were established because of the high median age (60-75 years) of the MD...
متن کاملImmune Mechanisms in Myelodysplastic Syndrome
Myelodysplastic syndrome (MDS) is a spectrum of diseases, characterized by debilitating cytopenias and a propensity of developing acute myeloid leukemia. Comprehensive sequencing efforts have revealed a range of mutations characteristic, but not specific, of MDS. Epidemiologically, autoimmune diseases are common in patients with MDS, fueling hypotheses of common etiological mechanisms. Both inn...
متن کاملWT1 expression in myelodysplastic syndrome.
Myelodysplastic syndromes are a heterogeneous group of disorders characterized by ineffective hematopoiesis accompanied by morphologic dysplasia [1]. The underlying genetic lesions responsible for the pathogenesis of the disease remain largely elusive. In addition, the diagnosis of low-grade dysplastic process such as refractory anemia (RA) poses a challenge to the clinician as well as to the h...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1999
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199905010-00087